Crespine Gel
Viscosupplement for osteoarthritis of the knee and hip. 15 mg hyaluronic acid per ml, 14 mg of it cross-linked.
Product detailsInformation for healthcare professionals
Crespine Gel and Crespine Gel+
Both products are sterile, viscoelastic, biocompatible gel implants made of cross-linked hyaluronic acid. They are injected intra-articularly to supplement the altered synovial fluid in osteoarthritic joints and are indicated for osteoarthritis of the knee and hip.
Crespine Gel+
The same gel with 3 mg/ml of the local anaesthetic prilocaine hydrochloride. Twelve-month single-injection data published in 2026.
Product detailsAt a glance
| Measure | Crespine Gel | Crespine Gel+ |
|---|---|---|
| Indication | Osteoarthritis of the knee and hip | Osteoarthritis of the knee and hip |
| Hyaluronic acid per ml | 15 mg (14 mg cross-linked, 1 mg non-cross-linked) | 15 mg (14 mg cross-linked, 1 mg non-cross-linked) |
| Local anaesthetic | — | Prilocaine hydrochloride 3 mg/ml |
| Volume | 2 ml prefilled syringe with Luer-Lock | 2 ml prefilled syringe with Luer-Lock |
| Treatment regimen | One injection per joint and treatment cycle | One injection per joint and treatment cycle |
| Published follow-up | 9 months (Bashaireh et al., 2015) | 12 months (Suppan et al., 2026) |
| Storage | 2–25 °C, do not freeze | 2–25 °C, do not freeze |
| Shelf life | 3 years from date of manufacture | 3 years from date of manufacture |
| PZN (Germany) | 08509223 | 08509246 |
Both products are CE-marked medical devices and may only be administered by healthcare professionals authorised under the applicable national rules. The injection technique is decisive for the result.
Availability
Crespine Gel and Crespine Gel+ are supplied through our distribution partners. Healthcare professionals can contact us for the partner responsible for their country; companies interested in distribution can find the details on the partner page.